Jason P. Schwans
HSCI 354 - Department of Chemistry and Biochemistry, California State University, Long Beach
1250 Bellflower Boulevard, Long Beach, CA 90840-9507, USA
Phone: 562-985-7778
[email protected]
HSCI 354 - Department of Chemistry and Biochemistry, California State University, Long Beach
1250 Bellflower Boulevard, Long Beach, CA 90840-9507, USA
Phone: 562-985-7778
[email protected]
EDUCATION AND TRAINING
Jan. 2004 - July 2012 Postdoctoral research, Biochemistry, Stanford University, Stanford, CA
December 2003 Ph.D., Chemistry, University of Chicago, Chicago, IL
August 1998 M.S., Chemistry, University of Chicago, Chicago, IL
May 1997 B.A., Chemistry and Music (cum laude), Augustana College, Sioux Falls, SD
PROFESSIONAL APPOINTMENTS
Aug. 2018 – Present Associate Professor, Bioorganic chemistry and enzymology, California State University, Long Beach, CA
• Energetic and structural basis for mechanisms in organic chemistry with an emphasis on the organic chemistry of biological
reactions
• Energetic and structural basis of enzymatic catalysis
• Nucleic acid, amino acid, and peptide synthetic chemistry
Aug. 2016 – Present Co-PI of the MARC U*STAR Program at California State University, Long Beacha
•Co-PI of an NIH funded program at Cal. State Long Beach to increase diversity in biomedical research
(NIH T32 GM008074)
Aug. 2012 – Aug. 2018 Assistant Professor, Bioorganic chemistry and enzymology, California State University, Long Beach, CA
AWARDS
• 2019 CSULB CNSM Faculty Award for Excellence, a.k.a. The Pretty Darn Good Professor (PDGP) Award
• 2019 CSULB Outstanding Faculty Mentor for Student Engagement in Research, Scholarly and Creative Activity
• 2018 Mayfield Award, CSULB College of Natural Sciences and Mathematics, Student Sponsored Award for Excellence in Teaching
PUBLICATIONS
23. Nguyen SN, Flores A, Talamantes D, Dar F, Valdez, Schwans J, Berlemont R. “GeneHunt for rapid domain-specific annotation of glycoside hydrolases” Sci. Rep., 2019, 9, 10137.
22. Alvarado W, Bremer PL, Choy A, Dinh HN, Eung A, Gonzalez J, Ly P, Tran T, Nakayama K, Schwans JP, Sorin EJ. “Understanding the enzyme-ligand complex: Insights from all-atom simulations of butyrylcholinesterase inhibition” J. Biomol. Struct. Dyn., 2019, 26, 1-14.
21. Chang TC, Park JH, Colquhoun AN, Khoury CB, Seangmany NA, Schwans JP. “Evaluating the catalytic importance of a conserved Glu97 residue in triosephosphate isomerase” Biochem. Biophys. Res. Commun., 2018, 505, 492-497.
20. Pinney MM, Natarajan A, Yabukarski F, Sanchez DM, Liu F, Liang R, Doukov T, Schwans JP, Martinez TJ, Herschlag D. “Structural coupling throughout the active site hydrogen bond networks of ketosteroid isomerase and photoactive yellow protein” J. Am. Chem. Soc., 2018, 140, 9827-9843.
19. Corpuz N, Schwans JP. “Generation of a cysteine sulfinic acid analog for incorporation in peptides using solid phase peptide synthesis” Bioorg. Med. Chem. Lett., 2017, 27, 2410-2414.
18. Nakayama K*, Schwans JP*, Sorin EJ*, Tran T, Gonzalez J, Arteaga E, McCoy S, Alvarado W, “Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors” Bioorg. Med. Chem., 2017, 25, 3171-3181.
17. Gonzalez J, Ramirez J, Schwans JP. “Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase” Amino Acids, 2016, 48, 2755-2763.
16. Natarajan A, Yabukarski F, Lamba V, Schwans JP, Sunden F, Herschlag D. “Biophysics. Comment on “Extreme electric fields power catalysis in the active site of ketosteroid isomerase” Science, 2015, 349, 936.
15. Natarajan A, Schwans JP, Herschlag D. “Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site” J. Am. Chem. Soc., 2014, 136, 7643-7654.
14. Schwans JP, Hanoian P, Lengerich BJ, Sunden F, Gonzalez A, Tsai Y, Hammes-Schiffer S, Herschlag D. “Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site” Biochemistry, 2014, 53, 2541-2555.
13. Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. “Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase” Biochemistry, 2013, 52, 7840-7855.
12. Schwans JP, Sunden F, Lassila JK, Gonzalez A, Tsai Y, Herschlag D. “Use of anion-pi interactions to position the general base in ketosteroid isomerase” Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 11308-11313.
11. Sigala, PA*, Fafarman AT*, Schwans JP*, Fried SD, Fenn T, Caaveiro JM, Pybus B, Ringe D, Petsko GA, Boxer S, Herschlag D. “Quantitative dissection of hydrogen bond mediated proton transfer in the ketosteroid isomerase active site” Proc. Natl. Acad. Sci. U.S.A., 2013, 110, E2552-2561.
10. Ruben EA*, Schwans JP*, Sonnett M, Natarajan A, Gonzalez A, Tsai Y, Herschlag, D. “Ground state destabilization for a positioned general base in the ketosteroid isomerase active site” Biochemistry 2013, 52, 1074-1081.
9. Fafarman AT*, Sigala PA*, Schwans JP, Fenn T, Herschlag D, Boxer S. “Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase” Proc. Natl. Acad. Sci. U.S.A., 2012, 109, E299-308.
8. Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. “Evaluating the catalytic contribution from the oxyanion hole in ketosteroid isomerase” J. Am. Chem. Soc., 2011, 133, 20052-20055.
Correction: J. Am. Chem. Soc., 2016, 138, 7801-7802.
7. Forconi M*, Schwans JP*, Porecha R, Sengupta R, Piccirilli JA, Herschlag D. “2′-Fluoro substituents can mimic native 2′-hydroxyls within structured RNA” Chem. Biol., 2011, 18, 949-954.
6. Schwans JP*, Kraut DA*, Herschlag D. “Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase” Proc. Natl. Acad. Sci. U.S.A., 2009, 106, 14271-14275.
5. Das R, Kudaravalli M, Jonikas M, Laederach A, Fong R, Schwans JP, Baker D, Piccirilli JA, Altman RB, Herschlag D. “Structural inference of native and partially folded RNA by high-throughput contact mapping” Proc. Natl. Acad. Sci. U.S.A., 2008, 105, 4144-4149.
4. Schwans JP, Li NS, Piccirilli JA. “A packing density metric for exploring the interior of folded RNA molecules” Angew. Chem. Intl. Ed., 2004, 43, 3033-3037.
3. Gordon PM, Fong R, Deb SK, Li NS, Schwans JP, Ye JD, Piccirilli JA. “New strategies for exploring RNA’s 2′-OH expose the importance of solvent during group II intron catalysis” Chem. Biol., 2004, 11, 237-246.
2. Schwans JP, Cortez CN, Olvera JA, Piccirilli JA. “2′-Mercaptonucleotide interference reveals regions of close packing within folded RNA molecules” J. Am. Chem. Soc., 2003, 125, 10012-10018.
1. Hamm ML, Schwans JP, Piccirilli JA. “The hammerhead ribozyme catalyzes the deglycosylation of 2′-mercaptocytidine” J. Am. Chem. Soc., 2000, 122, 4223-4224.
*Equal contribution
GRANTS AND FELLOWSHIPS
7. “Collaborative Research: Systematic Investigation of the Structure, Dynamics, and Energetics of Hydrogen Bonds and the Protein Interior Using Ketosteroid Isomerase and Model Systems.” National Science Foundation (2017-2021).
6. “From Bioinformatics to Enzyme Biochemistry: Identification of New Catalysts for Biofuel Production” Multidisciplinary Project Award, Office of Research & Sponsored Programs, California State University, Long Beach (2017).
5. “Investigating General Base Catalysis in Triosephosphate Isomerase Using Unnatural Amino Acids” California State University Long Beach, Building Infrastructure Leading to Diversity Research Stimulation Grant Program (CSULB BUILD), National Institutes of Health (2015).
4. “Unnatural Amino Acid Mutagenesis to Investigate Enzymatic General Base Catalysis” Cottrell College Science Award, Research Corporation for Science Advancement (2013).
3. “Atomic Level Mutagenesis to Investigate Enzymatic General Base Catalysis” California State University Program for Education & Research in Biotechnology (CSUPERB) New Investigator Award (2013).
2. NIH Ruth L. Kirschstein National Research Service Award (2006).
1. Stanford Dean’s Fellowship (2004).
INVITED LECTURES
7. “How do enzymes work? Unraveling enzyme function at a primarily undergraduate institution” (2018) Dan Herschlag Honorary Symposium, Stanford University, Stanford, California.
6. “How do enzymes work? Combining organic chemistry and biochemistry to investigate cholinesterase inhibition and enzyme function” (2018) Department of Chemistry and Biochemistry, California State University, Los Angeles.
5. “How do enzymes work? Synthesis and biochemical approaches to investigate cholinesterase inhibition and enzyme function” (2017) Department of Chemistry and Biochemistry, California State University, Long Beach.
4. “Site-directed and unnatural amino acid mutagenesis to investigate enzyme function” (2017) CSU Program in Biotechnology (CSUPERB), Santa Clara, CA.
3. “How do enzymes work? Using atomic level mutagenesis to investigate enzyme function” (2015) Department of Chemistry and Biochemistry, California State University, Fullerton.
2. “Taking apart enzymes like never before: Site-directed and atomic level mutagenesis to study enzyme function” (2014) Department of Chemistry and Biochemistry, California State University, San Francisco.
1. “The next generation of enzymology: Atomic level mutagenesis” (2014) CNSM Faculty Research Symposium, Department of Chemistry and Biochemistry, California State University, Long Beach.
CONFERENCE PARTICIPATION (Regional and National Meetings While at CSULB)
(Presenter(s) underlined; * = undergraduate student; ** = graduate student)
46. Aaron Chavarria*, Jeanna Young*, Vi Pham* and Jason Schwans (accepted) “Effect of Electron Withdrawing Groups on Benzoyl Amino Acids for Butyrylcholinesterase Inhibition in the Potential Treatment of Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
45. Amanda Sibayan*, Bianca Pingul* and Jason Schwans (accepted) “Lysine Based Fmoc-Amino Acid Esters as Butyrylcholinesterase Inhibitors in the Treatment of Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
44. Jubilee Munozvilla*, Christian Loo* and Jason Schwans (accepted) “Expanding the Use of Tyrosine Phenol Lyase in the Enzymatic Synthesis of Naphthol Unnatural Amino Acids” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
43. Merin Rixen*, Jennifer Ramierz* and Jason Schwans (accepted) “Evaluating a Series of Fmoc-Leucine Based Amino Acids to Identify Potent Butyrylcholinesterase Inhibitors as Potential Therapeutics to Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
42. Michael Lam*, Jennifer Ramierz* and Jason Schwans (accepted) “Fmoc-Dipeptides as a Scaffold to Systematically Investigate Inhibitors of Butyrylcholinesterase, an Enzyme Implicated in Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
41. Nicole Paz-Bracamonte*, Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (accepted) “Incorporating Substrate Features in Fmoc-Amino Acids to Develop More Potent and Specific Butyrylcholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
40. Michael Lam* and Jason Schwans (2019) “Investigating the Role of Stereochemistry in the Development of Cholinesterase Inhibitors to Treat Alzheimer’s Disease” SoCal Undergraduate Research Symposium in Chemistry, Irvine, CA.
39. Michael Lam* and Jason Schwans (2019) “Investigating the Role of Stereochemistry in the Development of Cholinesterase Inhibitors to Treat Alzheimer’s Disease” Southern California Undergraduate Research Conference (SCURC), Los Angeles, CA.
38. Martin Yau*, Phil Ly**, Kensaku Nakayama and Jason Schwans (2019) “Investigation Organobisthiophosphates as Cholinesterase Inhibitors: Balancing Application as Potential Therapeutics While Minimizing Pharmaceutical Pollution” Southern California Society of Environmental Toxicology and Chemistry Conference, San Diego, CA.
37. Noelle Alexa Novales* and Jason Schwans (2018) “Investigating Cosolvent Effects on Cholinesterases to Aid in Drug Solubility” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
36. Bianca Pingul*, Jennifer Ramirez* and Jason Schwans (2018) “Synthesis and Characterization of Esters of Fmoc-Amino Acids as Potential Butyrylcholinesterase Inhibitors” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
35. Noelle Alexa Novales* and Jason Schwans (2018) “Investigating Cosolvent Effects on Cholinesterases to Aid in Drug Solubility” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
34. Noel Chau*, Alex Colla** and Jason Schwans (2018) “Developing Approaches to Incorporate Fluorotyrosines in Peptides via Solid Phase Peptide Synthesis” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
33. Jeana Young*, Vi Pham* and Jason Schwans (2018) “Evaluating Benzoyl Amino Acids as Selective Inhibitors of BChE” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
32. Bianca Pingul*, Jennifer Ramirez* and Jason Schwans (2018) “Synthesis and Characterization of Esters of Fmoc-Amino Acids as Potential Butyrylcholinesterase Inhibitors” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
31. Adan Arizmendi* and Jason Schwans (2018) “Assessing the Stability of tert-Butyl Carbonate (Boc) and tert-Butyl (t-Butyl) as Protecting Groups for Fluorinated Phenols Under Solid Phase Peptide Synthesis Conditions: Model Studies for the Incorporation of Fluoro-substituted Tyrosines in Peptides and Proteins” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
30. Noel Chau*, Alex Colla** and Jason Schwans (2018) “Developing Approaches to Incorporate Fluorotyrosines in Peptides via Solid Phase Peptide Synthesis” SoCal Undergraduate Research Symposium in Chemistry, Irvine, CA.
29. Bianca Pingul*, Jennifer Ramirez* and Jason Schwans (2018) “Synthesis and Characterization of Esters of Fmoc-Amino Acids as Potential Butyrylcholinesterase Inhibitors” SoCal Undergraduate Research Symposium in Chemistry, Irvine, CA.
28. Julie Heejin Park**, Timothy Chang** and Jason Schwans (2018) “Evaluating the Catalytic Role of a Conserved Non-Active Site Residue in Triosephosphate Isomerase” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, San Diego, CA.
27. Noel Chau*, Alex Colla** and Jason Schwans (2018) “Developing an Efficient Method for the Incorporation of a Series of Fluorotyrosines in Peptides via Solid Phase Peptide Synthesis” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, San Diego, CA.
26. Julie Heejin Park**, Timothy Chang** and Jason Schwans (2018) “Evaluating the Catalytic Role of a Conserved Non-Active Site Residue in Triosephosphate Isomerase” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
25. Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (2018) “Examining Fmoc-Amino Acid Derivatives as Selective Inhibitors of Butyrylcholinesterase” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
24. Christian Loo*, Vannalyn Abilee, and Jason Schwans “Enzymatic Synthesis of a Naphthol Analog of Tyrosine” 2017 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Phoenix, AZ.
23. Jason Schwans, Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Sean McCoy*, Kensaku Nakayama and Eric Sorin (2017) “Investigating Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, Chicago, Il.
22. Chris Khoury**, Nessa Seangmany**, Timothy Chang** and Jason Schwans (2017) “Evaluating the Structural Role of a Conserved Glutamate Residue in Trypanosoma brucei brucei Triosephosphate Isomerase” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, Chicago, Il.
21. Jason Schwans, Jennifer Ramirez* and Jeannette Gonzalez* (2017) “Evaluating Fmoc-Amino Acids as Butyrylcholinesterase Inhibitors” American Chemical Society (ACS) National Meeting, San Francisco, CA.
20. Noel Chau*, Alex Colla** and Jason Schwans (2017) “Developing an Efficient Method for the Incorporation of a Series of Fluorotyrosines in Peptides via Solid Phase Peptide Synthesis” American Chemical Society (ACS) National Meeting, San Francisco, CA.
19. Helen Dinh*, Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Jacques Lowe*, Kensaku Nakayama and Jason Schwans (2017) “Evaluating Alkyl Cholinyl Phenyl Phosphates and an Ionizable Analog as Selective Butyrylcholinesterase Inhibitors” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
18. Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (2017) “Identifying Protected Amino Acids as a Class of Potent and Selective Butyrylcholinesterase Inhibitors” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
17. Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (2016) “Investigating Fmoc-Amino Acids as a Class of Butyrylcholinesterase Inhibitors” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Tampa, Fl.
16. Helen Dinh*, Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Jacques Lowe*, Kensaku Nakayama and Jason Schwans (2016) “Evaluating Alkyl Cholinyl Phenyl Phosphates and an Ionizable Analog as Selective Butyrylcholinesterase Inhibitors” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Tampa, Fl.
15. Noel Chau* and Jason Schwans (2016) “Investigating Substituted Phenols as Inhibitors for Cholinesterases” Southern California Conferences for Undergraduate Research, Riverside CA.
14. Nathan Alade**, Weilee Chen** and Jason Schwans (2016) “Uncovering Catalytic Role of an Active Site Lysine in Ribonuclease A” Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) National Conference, Long Beach, CA.
13. Anna Nguyen*, Ana Chan*, Nessa Seangmany** and Jason Schwans (2016) “Investigating the Catalytic Role of a Conserved Non-Active Site Residue in Triosephosphate Isomerase” Southern California Undergraduate Research Conference (SCURC), Long Beach, CA.
12. Jeannette Gonzalez*, Trina Tran**, Kensaku Nakayama and Jason Schwans (2016) “Evaluation of Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors” Southern California Undergraduate Research Conference (SCURC), Long Beach, CA.
11. Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (2016) “Investigating Fmoc-Amino Acids as a Class of Butyrylcholinesterase Inhibitors” Southern California Undergraduate Research Conference (SCURC), Long Beach, CA.
10. Nicholas Nieto* and Jason Schwans (2016) “Investigating Bisphosphates as Selective Butyrylcholinesterase Inhibitors for Treatment of Alzheimer’s Disease” Southern California Undergraduate Research Conference (SCURC), Long Beach, CA.
9. Nessa Seangmany**, Anna Nguyen*, Ana Chan* and Jason Schwans (2016) “Evaluating the Catalytic Role of a Conserved Glutamate Residue in Triosephosphate Isomerase” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, San Diego, CA.
8. Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Sean McCoy*, Kensaku Nakayama, Eric Sorin and Jason Schwans (2016) “Investigation of Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Garden Grove, CA.
7. Nicholas Nieto*, Karlo Artiga*, Trina Tran*, Kensaku Nakayama and Jason Schwans (2015) “Investigating Bisphosphates as Selective Butyrylcholinesterase Inhibitors for Potential Treatment of Alzheimer’s Disease” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Seattle, WA.
6. Jocelyn Ochoa*, Trina Tran**, Minh Nguyen*, Phong Ahn Nguyen*, Jaques Lowe*, Jeannette Gonzalez*, Jason Schwans and Kensaku Nakayama (2015) “Dialkyl Aryl Phosphates and Alkyl Aryl Cholinyl Phosphate Iodides as Potent Inhibitors of Butyrylcholinesterase” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Seattle, WA.
5. Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Sean McCoy*, Kensaku Nakayama, Eric Sorin and Jason Schwans (2015) “Investigation of Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors” UC Irvine Undergraduate Chemistry Symposium, Irvine, CA.
4. Ambreen Tahira**, Trina Tran**, Kim Tu**, Nicholas Nieto*, Karlo Artiga*, Roger Acey, Jason Schwans and Kensaku Nakayama (2015) “Synthesis of Bivalent Organothiophosphate Inhibitors and Their Inhibition of Butyrylcholinesterase: Studies Towards a Potential Treatment of Alzheimer’s Disease” American Chemical Society (ACS) Western Regional Meeting, San Marcos, CA.
3. Trina Tran**, Jocelyn Ochoa*, Jeannette Gonzalez*, Sean McCoy*, Jason Schwans, Eric Sorin and Kensaku Nakayama (2015) “Aryl Dibutyl Phosphates and Their Analogs as Selective Inhibitors of Butyrylcholinesterase: Compounds with Potential for the Treatment of Alzheimer’s Disease” American Chemical Society (ACS) Western Regional Meeting, San Marcos, CA.
2. Alex Colla**, Dagoberto Ramos* and Jason Schwans, (2015) “Development of an Efficient Approach for the Incorporation of a Series of Fluorotyrosines in Peptides” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
1. Ashley Torres* and Jason Schwans (2014) “Investigating the Catalytic Importance of a Conserved Non-Active Site Residue in Triose Phosphate Isomerase” Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) National Conference, Los Angeles, CA.
TEACHING EXPERIENCE
UNIVERSITY AND COMMUNITY SERVICE ACTIVITES
1. Membership and positions on faculty committees and activities
2. Activities in professional community
Jan. 2004 - July 2012 Postdoctoral research, Biochemistry, Stanford University, Stanford, CA
December 2003 Ph.D., Chemistry, University of Chicago, Chicago, IL
August 1998 M.S., Chemistry, University of Chicago, Chicago, IL
May 1997 B.A., Chemistry and Music (cum laude), Augustana College, Sioux Falls, SD
PROFESSIONAL APPOINTMENTS
Aug. 2018 – Present Associate Professor, Bioorganic chemistry and enzymology, California State University, Long Beach, CA
• Energetic and structural basis for mechanisms in organic chemistry with an emphasis on the organic chemistry of biological
reactions
• Energetic and structural basis of enzymatic catalysis
• Nucleic acid, amino acid, and peptide synthetic chemistry
Aug. 2016 – Present Co-PI of the MARC U*STAR Program at California State University, Long Beacha
•Co-PI of an NIH funded program at Cal. State Long Beach to increase diversity in biomedical research
(NIH T32 GM008074)
Aug. 2012 – Aug. 2018 Assistant Professor, Bioorganic chemistry and enzymology, California State University, Long Beach, CA
AWARDS
• 2019 CSULB CNSM Faculty Award for Excellence, a.k.a. The Pretty Darn Good Professor (PDGP) Award
• 2019 CSULB Outstanding Faculty Mentor for Student Engagement in Research, Scholarly and Creative Activity
• 2018 Mayfield Award, CSULB College of Natural Sciences and Mathematics, Student Sponsored Award for Excellence in Teaching
PUBLICATIONS
23. Nguyen SN, Flores A, Talamantes D, Dar F, Valdez, Schwans J, Berlemont R. “GeneHunt for rapid domain-specific annotation of glycoside hydrolases” Sci. Rep., 2019, 9, 10137.
22. Alvarado W, Bremer PL, Choy A, Dinh HN, Eung A, Gonzalez J, Ly P, Tran T, Nakayama K, Schwans JP, Sorin EJ. “Understanding the enzyme-ligand complex: Insights from all-atom simulations of butyrylcholinesterase inhibition” J. Biomol. Struct. Dyn., 2019, 26, 1-14.
21. Chang TC, Park JH, Colquhoun AN, Khoury CB, Seangmany NA, Schwans JP. “Evaluating the catalytic importance of a conserved Glu97 residue in triosephosphate isomerase” Biochem. Biophys. Res. Commun., 2018, 505, 492-497.
20. Pinney MM, Natarajan A, Yabukarski F, Sanchez DM, Liu F, Liang R, Doukov T, Schwans JP, Martinez TJ, Herschlag D. “Structural coupling throughout the active site hydrogen bond networks of ketosteroid isomerase and photoactive yellow protein” J. Am. Chem. Soc., 2018, 140, 9827-9843.
19. Corpuz N, Schwans JP. “Generation of a cysteine sulfinic acid analog for incorporation in peptides using solid phase peptide synthesis” Bioorg. Med. Chem. Lett., 2017, 27, 2410-2414.
18. Nakayama K*, Schwans JP*, Sorin EJ*, Tran T, Gonzalez J, Arteaga E, McCoy S, Alvarado W, “Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors” Bioorg. Med. Chem., 2017, 25, 3171-3181.
17. Gonzalez J, Ramirez J, Schwans JP. “Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase” Amino Acids, 2016, 48, 2755-2763.
16. Natarajan A, Yabukarski F, Lamba V, Schwans JP, Sunden F, Herschlag D. “Biophysics. Comment on “Extreme electric fields power catalysis in the active site of ketosteroid isomerase” Science, 2015, 349, 936.
15. Natarajan A, Schwans JP, Herschlag D. “Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site” J. Am. Chem. Soc., 2014, 136, 7643-7654.
14. Schwans JP, Hanoian P, Lengerich BJ, Sunden F, Gonzalez A, Tsai Y, Hammes-Schiffer S, Herschlag D. “Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site” Biochemistry, 2014, 53, 2541-2555.
13. Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. “Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase” Biochemistry, 2013, 52, 7840-7855.
12. Schwans JP, Sunden F, Lassila JK, Gonzalez A, Tsai Y, Herschlag D. “Use of anion-pi interactions to position the general base in ketosteroid isomerase” Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 11308-11313.
11. Sigala, PA*, Fafarman AT*, Schwans JP*, Fried SD, Fenn T, Caaveiro JM, Pybus B, Ringe D, Petsko GA, Boxer S, Herschlag D. “Quantitative dissection of hydrogen bond mediated proton transfer in the ketosteroid isomerase active site” Proc. Natl. Acad. Sci. U.S.A., 2013, 110, E2552-2561.
10. Ruben EA*, Schwans JP*, Sonnett M, Natarajan A, Gonzalez A, Tsai Y, Herschlag, D. “Ground state destabilization for a positioned general base in the ketosteroid isomerase active site” Biochemistry 2013, 52, 1074-1081.
9. Fafarman AT*, Sigala PA*, Schwans JP, Fenn T, Herschlag D, Boxer S. “Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase” Proc. Natl. Acad. Sci. U.S.A., 2012, 109, E299-308.
8. Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. “Evaluating the catalytic contribution from the oxyanion hole in ketosteroid isomerase” J. Am. Chem. Soc., 2011, 133, 20052-20055.
Correction: J. Am. Chem. Soc., 2016, 138, 7801-7802.
7. Forconi M*, Schwans JP*, Porecha R, Sengupta R, Piccirilli JA, Herschlag D. “2′-Fluoro substituents can mimic native 2′-hydroxyls within structured RNA” Chem. Biol., 2011, 18, 949-954.
6. Schwans JP*, Kraut DA*, Herschlag D. “Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase” Proc. Natl. Acad. Sci. U.S.A., 2009, 106, 14271-14275.
5. Das R, Kudaravalli M, Jonikas M, Laederach A, Fong R, Schwans JP, Baker D, Piccirilli JA, Altman RB, Herschlag D. “Structural inference of native and partially folded RNA by high-throughput contact mapping” Proc. Natl. Acad. Sci. U.S.A., 2008, 105, 4144-4149.
4. Schwans JP, Li NS, Piccirilli JA. “A packing density metric for exploring the interior of folded RNA molecules” Angew. Chem. Intl. Ed., 2004, 43, 3033-3037.
3. Gordon PM, Fong R, Deb SK, Li NS, Schwans JP, Ye JD, Piccirilli JA. “New strategies for exploring RNA’s 2′-OH expose the importance of solvent during group II intron catalysis” Chem. Biol., 2004, 11, 237-246.
2. Schwans JP, Cortez CN, Olvera JA, Piccirilli JA. “2′-Mercaptonucleotide interference reveals regions of close packing within folded RNA molecules” J. Am. Chem. Soc., 2003, 125, 10012-10018.
1. Hamm ML, Schwans JP, Piccirilli JA. “The hammerhead ribozyme catalyzes the deglycosylation of 2′-mercaptocytidine” J. Am. Chem. Soc., 2000, 122, 4223-4224.
*Equal contribution
GRANTS AND FELLOWSHIPS
7. “Collaborative Research: Systematic Investigation of the Structure, Dynamics, and Energetics of Hydrogen Bonds and the Protein Interior Using Ketosteroid Isomerase and Model Systems.” National Science Foundation (2017-2021).
6. “From Bioinformatics to Enzyme Biochemistry: Identification of New Catalysts for Biofuel Production” Multidisciplinary Project Award, Office of Research & Sponsored Programs, California State University, Long Beach (2017).
5. “Investigating General Base Catalysis in Triosephosphate Isomerase Using Unnatural Amino Acids” California State University Long Beach, Building Infrastructure Leading to Diversity Research Stimulation Grant Program (CSULB BUILD), National Institutes of Health (2015).
4. “Unnatural Amino Acid Mutagenesis to Investigate Enzymatic General Base Catalysis” Cottrell College Science Award, Research Corporation for Science Advancement (2013).
3. “Atomic Level Mutagenesis to Investigate Enzymatic General Base Catalysis” California State University Program for Education & Research in Biotechnology (CSUPERB) New Investigator Award (2013).
2. NIH Ruth L. Kirschstein National Research Service Award (2006).
1. Stanford Dean’s Fellowship (2004).
INVITED LECTURES
7. “How do enzymes work? Unraveling enzyme function at a primarily undergraduate institution” (2018) Dan Herschlag Honorary Symposium, Stanford University, Stanford, California.
6. “How do enzymes work? Combining organic chemistry and biochemistry to investigate cholinesterase inhibition and enzyme function” (2018) Department of Chemistry and Biochemistry, California State University, Los Angeles.
5. “How do enzymes work? Synthesis and biochemical approaches to investigate cholinesterase inhibition and enzyme function” (2017) Department of Chemistry and Biochemistry, California State University, Long Beach.
4. “Site-directed and unnatural amino acid mutagenesis to investigate enzyme function” (2017) CSU Program in Biotechnology (CSUPERB), Santa Clara, CA.
3. “How do enzymes work? Using atomic level mutagenesis to investigate enzyme function” (2015) Department of Chemistry and Biochemistry, California State University, Fullerton.
2. “Taking apart enzymes like never before: Site-directed and atomic level mutagenesis to study enzyme function” (2014) Department of Chemistry and Biochemistry, California State University, San Francisco.
1. “The next generation of enzymology: Atomic level mutagenesis” (2014) CNSM Faculty Research Symposium, Department of Chemistry and Biochemistry, California State University, Long Beach.
CONFERENCE PARTICIPATION (Regional and National Meetings While at CSULB)
(Presenter(s) underlined; * = undergraduate student; ** = graduate student)
46. Aaron Chavarria*, Jeanna Young*, Vi Pham* and Jason Schwans (accepted) “Effect of Electron Withdrawing Groups on Benzoyl Amino Acids for Butyrylcholinesterase Inhibition in the Potential Treatment of Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
45. Amanda Sibayan*, Bianca Pingul* and Jason Schwans (accepted) “Lysine Based Fmoc-Amino Acid Esters as Butyrylcholinesterase Inhibitors in the Treatment of Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
44. Jubilee Munozvilla*, Christian Loo* and Jason Schwans (accepted) “Expanding the Use of Tyrosine Phenol Lyase in the Enzymatic Synthesis of Naphthol Unnatural Amino Acids” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
43. Merin Rixen*, Jennifer Ramierz* and Jason Schwans (accepted) “Evaluating a Series of Fmoc-Leucine Based Amino Acids to Identify Potent Butyrylcholinesterase Inhibitors as Potential Therapeutics to Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
42. Michael Lam*, Jennifer Ramierz* and Jason Schwans (accepted) “Fmoc-Dipeptides as a Scaffold to Systematically Investigate Inhibitors of Butyrylcholinesterase, an Enzyme Implicated in Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
41. Nicole Paz-Bracamonte*, Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (accepted) “Incorporating Substrate Features in Fmoc-Amino Acids to Develop More Potent and Specific Butyrylcholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease” 2019 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Anaheim, CA.
40. Michael Lam* and Jason Schwans (2019) “Investigating the Role of Stereochemistry in the Development of Cholinesterase Inhibitors to Treat Alzheimer’s Disease” SoCal Undergraduate Research Symposium in Chemistry, Irvine, CA.
39. Michael Lam* and Jason Schwans (2019) “Investigating the Role of Stereochemistry in the Development of Cholinesterase Inhibitors to Treat Alzheimer’s Disease” Southern California Undergraduate Research Conference (SCURC), Los Angeles, CA.
38. Martin Yau*, Phil Ly**, Kensaku Nakayama and Jason Schwans (2019) “Investigation Organobisthiophosphates as Cholinesterase Inhibitors: Balancing Application as Potential Therapeutics While Minimizing Pharmaceutical Pollution” Southern California Society of Environmental Toxicology and Chemistry Conference, San Diego, CA.
37. Noelle Alexa Novales* and Jason Schwans (2018) “Investigating Cosolvent Effects on Cholinesterases to Aid in Drug Solubility” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
36. Bianca Pingul*, Jennifer Ramirez* and Jason Schwans (2018) “Synthesis and Characterization of Esters of Fmoc-Amino Acids as Potential Butyrylcholinesterase Inhibitors” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
35. Noelle Alexa Novales* and Jason Schwans (2018) “Investigating Cosolvent Effects on Cholinesterases to Aid in Drug Solubility” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
34. Noel Chau*, Alex Colla** and Jason Schwans (2018) “Developing Approaches to Incorporate Fluorotyrosines in Peptides via Solid Phase Peptide Synthesis” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
33. Jeana Young*, Vi Pham* and Jason Schwans (2018) “Evaluating Benzoyl Amino Acids as Selective Inhibitors of BChE” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
32. Bianca Pingul*, Jennifer Ramirez* and Jason Schwans (2018) “Synthesis and Characterization of Esters of Fmoc-Amino Acids as Potential Butyrylcholinesterase Inhibitors” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
31. Adan Arizmendi* and Jason Schwans (2018) “Assessing the Stability of tert-Butyl Carbonate (Boc) and tert-Butyl (t-Butyl) as Protecting Groups for Fluorinated Phenols Under Solid Phase Peptide Synthesis Conditions: Model Studies for the Incorporation of Fluoro-substituted Tyrosines in Peptides and Proteins” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Indianapolis, IN.
30. Noel Chau*, Alex Colla** and Jason Schwans (2018) “Developing Approaches to Incorporate Fluorotyrosines in Peptides via Solid Phase Peptide Synthesis” SoCal Undergraduate Research Symposium in Chemistry, Irvine, CA.
29. Bianca Pingul*, Jennifer Ramirez* and Jason Schwans (2018) “Synthesis and Characterization of Esters of Fmoc-Amino Acids as Potential Butyrylcholinesterase Inhibitors” SoCal Undergraduate Research Symposium in Chemistry, Irvine, CA.
28. Julie Heejin Park**, Timothy Chang** and Jason Schwans (2018) “Evaluating the Catalytic Role of a Conserved Non-Active Site Residue in Triosephosphate Isomerase” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, San Diego, CA.
27. Noel Chau*, Alex Colla** and Jason Schwans (2018) “Developing an Efficient Method for the Incorporation of a Series of Fluorotyrosines in Peptides via Solid Phase Peptide Synthesis” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, San Diego, CA.
26. Julie Heejin Park**, Timothy Chang** and Jason Schwans (2018) “Evaluating the Catalytic Role of a Conserved Non-Active Site Residue in Triosephosphate Isomerase” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
25. Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (2018) “Examining Fmoc-Amino Acid Derivatives as Selective Inhibitors of Butyrylcholinesterase” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
24. Christian Loo*, Vannalyn Abilee, and Jason Schwans “Enzymatic Synthesis of a Naphthol Analog of Tyrosine” 2017 Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Phoenix, AZ.
23. Jason Schwans, Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Sean McCoy*, Kensaku Nakayama and Eric Sorin (2017) “Investigating Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, Chicago, Il.
22. Chris Khoury**, Nessa Seangmany**, Timothy Chang** and Jason Schwans (2017) “Evaluating the Structural Role of a Conserved Glutamate Residue in Trypanosoma brucei brucei Triosephosphate Isomerase” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, Chicago, Il.
21. Jason Schwans, Jennifer Ramirez* and Jeannette Gonzalez* (2017) “Evaluating Fmoc-Amino Acids as Butyrylcholinesterase Inhibitors” American Chemical Society (ACS) National Meeting, San Francisco, CA.
20. Noel Chau*, Alex Colla** and Jason Schwans (2017) “Developing an Efficient Method for the Incorporation of a Series of Fluorotyrosines in Peptides via Solid Phase Peptide Synthesis” American Chemical Society (ACS) National Meeting, San Francisco, CA.
19. Helen Dinh*, Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Jacques Lowe*, Kensaku Nakayama and Jason Schwans (2017) “Evaluating Alkyl Cholinyl Phenyl Phosphates and an Ionizable Analog as Selective Butyrylcholinesterase Inhibitors” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
18. Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (2017) “Identifying Protected Amino Acids as a Class of Potent and Selective Butyrylcholinesterase Inhibitors” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
17. Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (2016) “Investigating Fmoc-Amino Acids as a Class of Butyrylcholinesterase Inhibitors” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Tampa, Fl.
16. Helen Dinh*, Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Jacques Lowe*, Kensaku Nakayama and Jason Schwans (2016) “Evaluating Alkyl Cholinyl Phenyl Phosphates and an Ionizable Analog as Selective Butyrylcholinesterase Inhibitors” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Tampa, Fl.
15. Noel Chau* and Jason Schwans (2016) “Investigating Substituted Phenols as Inhibitors for Cholinesterases” Southern California Conferences for Undergraduate Research, Riverside CA.
14. Nathan Alade**, Weilee Chen** and Jason Schwans (2016) “Uncovering Catalytic Role of an Active Site Lysine in Ribonuclease A” Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) National Conference, Long Beach, CA.
13. Anna Nguyen*, Ana Chan*, Nessa Seangmany** and Jason Schwans (2016) “Investigating the Catalytic Role of a Conserved Non-Active Site Residue in Triosephosphate Isomerase” Southern California Undergraduate Research Conference (SCURC), Long Beach, CA.
12. Jeannette Gonzalez*, Trina Tran**, Kensaku Nakayama and Jason Schwans (2016) “Evaluation of Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors” Southern California Undergraduate Research Conference (SCURC), Long Beach, CA.
11. Jennifer Ramirez*, Jeannette Gonzalez* and Jason Schwans (2016) “Investigating Fmoc-Amino Acids as a Class of Butyrylcholinesterase Inhibitors” Southern California Undergraduate Research Conference (SCURC), Long Beach, CA.
10. Nicholas Nieto* and Jason Schwans (2016) “Investigating Bisphosphates as Selective Butyrylcholinesterase Inhibitors for Treatment of Alzheimer’s Disease” Southern California Undergraduate Research Conference (SCURC), Long Beach, CA.
9. Nessa Seangmany**, Anna Nguyen*, Ana Chan* and Jason Schwans (2016) “Evaluating the Catalytic Role of a Conserved Glutamate Residue in Triosephosphate Isomerase” American Society for Biochemistry and Molecular Biology (ASBMB) National Meeting, San Diego, CA.
8. Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Sean McCoy*, Kensaku Nakayama, Eric Sorin and Jason Schwans (2016) “Investigation of Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Garden Grove, CA.
7. Nicholas Nieto*, Karlo Artiga*, Trina Tran*, Kensaku Nakayama and Jason Schwans (2015) “Investigating Bisphosphates as Selective Butyrylcholinesterase Inhibitors for Potential Treatment of Alzheimer’s Disease” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Seattle, WA.
6. Jocelyn Ochoa*, Trina Tran**, Minh Nguyen*, Phong Ahn Nguyen*, Jaques Lowe*, Jeannette Gonzalez*, Jason Schwans and Kensaku Nakayama (2015) “Dialkyl Aryl Phosphates and Alkyl Aryl Cholinyl Phosphate Iodides as Potent Inhibitors of Butyrylcholinesterase” Annual Biomedical Research Conference for Minority Students (ABRCMS) National Conference, Seattle, WA.
5. Jeannette Gonzalez*, Trina Tran**, Jocelyn Ochoa*, Sean McCoy*, Kensaku Nakayama, Eric Sorin and Jason Schwans (2015) “Investigation of Dialkyl Aryl Phosphates as Selective Butyrylcholinesterase Inhibitors” UC Irvine Undergraduate Chemistry Symposium, Irvine, CA.
4. Ambreen Tahira**, Trina Tran**, Kim Tu**, Nicholas Nieto*, Karlo Artiga*, Roger Acey, Jason Schwans and Kensaku Nakayama (2015) “Synthesis of Bivalent Organothiophosphate Inhibitors and Their Inhibition of Butyrylcholinesterase: Studies Towards a Potential Treatment of Alzheimer’s Disease” American Chemical Society (ACS) Western Regional Meeting, San Marcos, CA.
3. Trina Tran**, Jocelyn Ochoa*, Jeannette Gonzalez*, Sean McCoy*, Jason Schwans, Eric Sorin and Kensaku Nakayama (2015) “Aryl Dibutyl Phosphates and Their Analogs as Selective Inhibitors of Butyrylcholinesterase: Compounds with Potential for the Treatment of Alzheimer’s Disease” American Chemical Society (ACS) Western Regional Meeting, San Marcos, CA.
2. Alex Colla**, Dagoberto Ramos* and Jason Schwans, (2015) “Development of an Efficient Approach for the Incorporation of a Series of Fluorotyrosines in Peptides” California State University Program for Education & Research in Biotechnology (CSUPERB) Annual Biotechnology Symposium, Santa Clara, CA.
1. Ashley Torres* and Jason Schwans (2014) “Investigating the Catalytic Importance of a Conserved Non-Active Site Residue in Triose Phosphate Isomerase” Society for Advancement of Chicanos/Hispanics and Native Americans in Science (SACNAS) National Conference, Los Angeles, CA.
TEACHING EXPERIENCE
- CHEM 111A Lab (General Chemistry Laboratory)
- CHEM 220A (Organic Chemistry I)
- CHEM 220B (Organic Chemistry II)
- CHEM 223A (Organic Chemistry Laboratory I for Nonmajors)
- CHEM 224A (Organic Chemistry I Recitation)
- CHEM 224B (Organic Chemistry II Recitation)
- CHEM 320L (Organic Chemistry Laboratory for Majors)
- CHEM 541 (Biochemistry Core for Graduate Study)
- CHEM 582 (Organic Mechanisms of Biological Reactions)
- CHEM 595A (Colloquium in Biochemistry)
- NSCI 190A (Experience Success Program for First Year Students in STEM)
UNIVERSITY AND COMMUNITY SERVICE ACTIVITES
1. Membership and positions on faculty committees and activities
- Organic chemistry faculty hiring committee (Chair; Fall 2019—present)
- General Education Governing Committee (GEGC) (Fall 2019—present)
- CNSM Faculty Learning Program (FLP) leader (Summer 2019—present)
- Jensen Student Access to Science and Math Center (SAS) Research Program Coordinator hiring committee (Summer 2018)
- Biochemistry faculty hiring committee (Fall 2017—Spring 2018)
- BUILD Learning Community leader (Fall 2017—Spring 2018)
- University Honors Council (Spring 2017—present)
- University Academic Appeals committee (Fall 2015—Spring 2018, Fall 2019—current ; Chair Fall 2017—Spring 2018)
- Co-PI of the MARC U*STAR program (Fall 2016—present)
- Departmental curriculum committee (Fall 2013—Spring 2016; Chair Fall 2017—Fall 2018)
- Acting faculty PI for the MARC U*STAR program (Fall 2015—Fall 2016)
- College Grade Appeals committee (Chair) (Fall 2014—Spring 2015)
- Biochemistry graduate admissions (Spring 2015—present)
- CNSM Faculty Research Symposium organization committee (Spring 2015)
- MARC U*STAR/Bridges to the Baccalaureate Coordinator of Research Programs hiring committee (Spring 2015)
- Jensen Student Access to Science and Math Center (SAS) Coordinator hiring committee (Spring 2015)
- ORSP hiring committee for grants development specialist (Fall 2014—Spring 2015)
- Analytical chemistry faculty hiring committee (Fall 2014—Spring 2015)
- Biochemistry faculty hiring committee (Fall 2013—Spring 2014)
- 595 rubric revision committee (Spring 2013)
- Department recording secretary (Fall 2012—Fall 2014)
- Department elections committee (Fall 2012—Spring 2014; Fall 2017—Spring 2018)
2. Activities in professional community
- Member of the American Chemical Society (1993—present)
- Member of the American Society for Biochemistry and Molecular Biology (2016—present)
- Participant on CSUPERB grant review panels
- Peer reviewer for PLoS One, BBA Proteins and Proteomics, BMC Research Notes, J Peptide Science, Letters in Organic Chemistry, and Protein and Peptide Letters